Amp Regulated
Amp Regulated

The role of histamine in the mentally ill and its attenuation by vitamin C – Part III
Chapter 5: Conclusions, Implications and recommendations for future research
Conclusions and implications:
The role of histamine in mental illness has been theorized for several decades, but both conventional and alternative medical fields have been slow to observe the influence of histamine in mental health. In addition, the vast majority of conventional and alternative practitioners are unaware that vitamin C has potent effects antihistamine, which may be beneficial to both physical and mental health. The conventional medicine antihistamines used to treat histamine-related pharmaceutical physical complaints, and sometimes mental. As mentioned above, pharmaceutical antihistamines have several side effects, many of which are in poorer health mental. It is unfortunate that the vast majority of medical alternatives are ignorant of the effects of vitamin C antihistamine. It is the purpose of this thesis to convey the effects of antihistamines, vitamin C, especially as regards treatment of various forms of mental illness.
Proof of the positive impact of the vitamin C on mental health is convincing. Vitamin C can act as a mild antidepressant by increasing levels of cAMP. Low levels of cAMP are associated with depression. Vitamin C also helps to produce norepinephrine, which, as the camp is often low in depression. Indeed, The camp is down the path of norepinephrine, which is how many antidepressant drug used to improve mood. Vitamin C hydroxy dopamine also to help train norepinephrine (Goodman et al., 1996).
Vitamin C, when used at high doses, which may reduce anxiety (Balch and Balch, 1997). As mentioned previously, the brain is constantly maintained constant levels of vitamin C, no matter how low levels are in the rest of the body. Thus, the question arises: how can the low levels of vitamin D or high health mental, if not in a constant concentration in the brain? A possible explanation is as follows: the group of Vitamin C Total Body may become more oxidized than reduced. Note that only oxidized vitamin C enters the brain, where it is reduced. If insufficient reducing agents into the brain, then oxidized Vitamin C remain, as most of its properties rendered useless. Reduction of vitamin C modulates levels of dopamine in the brain, and therefore both can act as an antipsychotic Natural reducing high levels of dopamine. It also helps to secrete oxytocin, a hormone of pleasure, hence the improvement mood. As mentioned above, "the promotion of ascorbate formation of myelin (Rice, 2000, p. 214). Vitamin C also inhibits release of the stress hormone cortisol, which over long periods can precipitate depression. It also helps protect the brain against neurotoxicity induced by the drug, probably by its antioxidant effects.
However, by far the largest positive effect on mental health than vitamin C has an antihistamine effect. This is because, as mentioned above, histamine has several adverse effects on mental health. Administration of histamine in the brains of animals enhanced fear memory (Blandina et al., 2004). It is well known that histamine plays a role important in allergic reactions, and people with allergies are much more likely to suffer from depression (Firshein, 1996; Ossofsky, 1976). Histamine can directly cause depression behavior (Arrigo-Reina and Chiechio, 1998).
As mentioned above, histamine, either directly or indirectly influence all neurotransmitters main, often by inhibiting the release of neurotransmitters (Brown, Stevens, and Haas, 2001), which theoretically causing anxiety, depression, or both. Anxiety can be caused by inhibition of histamine, GABA, which decreases nerve transmission. Depression can be caused by inhibition of the antidepressant "neurotransmitters serotonin and noradrenaline. However, histamine can also release norepinephrine (Bugajski, 1984) with it causing anxiety or mania. Often Stress releases histamine, which in turn will help unlock the HPA axis stress hormones. It is known that chronic activation HPA is associated with depression and disorders of the brain. There is also evidence that histamine activated via the track more calcium than DAG (Sarri, croutons, and Claro, 1995). There is abundant evidence that the DAG path is an antidepressant type, and the calcium channel can cause depression.
In addition to its antihistamine effect, there are several sources of evidence that suggests that humans should take supplements of vitamin C. Dr. Linus Pauling, twice Nobel Laureate, believes that adults need between man and nine grams of vitamin C per day (Haas, 1992). Animals are the synthesis of vitamin C can make 45-300 times the RDA adult human is about 0.9 mg / kg / day (60-90 mg / day) (Levine, 1985). To be a 150-pound human, this extrapolated to about 12 grams per day, if human beings synthesize their own vitamin C. Vitamin C blood and tissues decreases with age (Lieberman and Bruning, 1997), which is another reason to complete. If vitamin C is considered as a supplement supplements should then consider others, because the requirements of vitamin C in calcium, magnesium, bioflavonoids, and help its own assimilation (Balch and Balch, 1997).
Recommendations for future research:
Because vitamin C and histamine are involved in both physical processes and mentally, which leads to the question of psychosomatic problems and the two molecules. Recall that the two molecules are also involved in the response immune and pro-or anti-allergic responses. There are three possible links between psychological and somatic state of allergy. The first is that allergies are caused by psychological stress. The second is that psychological stress is caused by allergies. The third is that exposure can produce answers allergic to both psychological and somatic. This third link has been demonstrated in a double blind study (King, 1981). As mentioned above, the release of histamine-mediated allergy is associated with several mental reactions.
There have been various theories about the molecular basis mental illness for several decades. The first theory is called the theory monoamines formed in 1950 and 1960. It is suggested that brain abnormal is directly dependent on the fluctuating levels of monoamine (serotonin, norepinephrine, dopamine, GABA). Interestingly, histamine did not appear not in the theory of monoamine origin, probably due to the lack of investigation both as to its effects on mental health. At that time, Most doctors usually give antidepressants for depressed patients only, and benzodiazepines (eg Xanax, Valium) for Anxious. The second theory is the theory of comorbidity, psychiatric philosophy that dominated the 1990s. It was formed following the recognition Medications like Prozac, without the aid can reduce depression and anxiety. The third is the subsyndromal theory, which has evolved the discovery that vast majority of people want to experience depression, and vice versa. The philosophy of the theory is essentially in subsyndromal the middle of the monoamine theories and comorbidity.
The discovery that histamine can inhibit all the other important neurotransmitters suggests take another look at the monoamine hypothesis behind the mental illness. It is known that dopamine tends to be high in psychotic mania noradrenaline serotonin in the high and low in depression. One might assume that the psychotic dopamine neurotransmitter system have dominated the neurotransmitter norepinephrine Bipolar dominated, and serotonin, a neurotransmitter system depressant dominated. The fourth major monoamine, histamine, may be dominant in atopic (allergic) individuals. People mainly histaminergic neurotransmitter systems could have a wide variety of mental illnesses, and that histamine affects the release of all the most important neurotransmitters. Biochemical characterization of histamine person may be of interest to professionals to help that person physically and mentally. This characterization leads to the question of writing described metabolic below.
In emerging nutrition science writing metabolic calls for a series of questions to determine what type of Biochemistry have. Some people are slow oxidizers tend to be dominant in the sympathetic system. They get better results in carbohydrates. Other are fast oxidizers tend to be the dominant parasympathetic nervous system. These people do better with more fat and protein in your diet. Too many carbs during rapid oxidation can lead to many physical and mental problems. Since histamine is a stimulant molecule, which can accelerate the oxidation, and histamine types may want to consider limiting carbohydrates.
There is some evidence to suggest that histamine is involved in the creation of biochemistry parasympathetic dominant person. The parasympathetic branch of the central nervous system is responsible the decrease in heart rate and an increase in digestive secretions of which are also caused by the release of histamine. In addition, the dominant trends of physics parasympathetic allergies and overfeeding (Wolcott and Fahey, 2002). Histamine is a major cause of allergies and its stimulating effect on digestion can lead to excessive eating.
In addition to its antihistamine effect, Vitamin C can help to Biochemistry a person in another, more subtle. Vitamin C can be purchased as ascorbic acid or right neutral pH calcium ascorbate or ascorbate sodium. For those who are sympathetic dominant, right ascorbic acid should be considered, since the types of people do not have enough fluids hydrochloric acid. Hydrogen ascorbic acid dissociate weakly bound hydroxyl group in the stomach and facilitate digestion of proteins. Acid ascorbic acid may also be useful for balancing the pH of the blood of people with metabolic alkalosis.
In contrast, the parasympathetic system, which tend to have a strong production of hydrochloric acid, calcium ascorbate should try and accept that the ions of excess ascorbate hydrogen in the stomach. Calcium ascorbate at high doses can help neutralize acid reflux. Calcium is also good for parasympathetic in delaying oxidation (Wolcott and Fahey, 2002). calcium ascorbate can help balance the pH of the blood of people who have metabolic acidosis.
Other future research could focus on how megadoses of vitamin C affects the mental health quantitatively. There has been some research showing that consumption of vitamin C improves mood (Brody, 2002; Balch and Balch, 1997). So far, there has been a large study to see whether vitamin C alone can reduce significant depression or anxiety, either in conventional medicine or alternative. There are two main clinical scales measure depression and anxiety scale — Hamilton Depression and Hamilton Anxiety Scale. It would be interesting see if vitamin C could significantly reduce depression alone and / or anxiety.
Because people have different atoms crooked different, the question arises how much vitamin C is needed daily by a person for the physical and mental health. One of the best ways assess the amount of vitamin C a person needs is to do their hunting ascorbic acid. This can be done both acid ascorbic acid and calcium ascorbate, sodium /. The protocol may vary, but usually comprises a person who takes 1-2 grams of vitamin C every hour until the Tolerance is colon (diarrhea). The grams of vitamin C are counted and recorded. The final program (s) that cause intestinal tolerance generally multiplied by 50-80%, which is the daily dose of reference, you should take next. For example, if 18 grams of tolerance allows intestine, 9.16 grams is the amount reference daily. If the person is under an unusual amount of stress or a viral infection, the baseline can be increased to bowel tolerance occurs at a higher level than before. Again, the new temporary intestinal tolerance is lowered to a certain percentage of the agent stress decreases.
Abstract:
The contents of this thesis has developed a multidimensional model for the attenuation mental illness associated with histamine by vitamin C. Both histamine and vitamin C on the human body at multiple levels. Histamine plays many different roles in the body, including neuromodulation, neurotransmission, mediated allergic inflammatory mediator and stimulator of the secretion gastric acid. When histamine levels are within normal range, the above process are generally balanced and functioning optimally. This is when histamine levels are very low or high, problems may occur. One function of vitamin C in the body is to modulate the levels histamine, and if the low levels of histamine, the administration of vitamin C will make small quantities of histamine to be released. When histamine levels are abnormally high, vitamin C acts as an antihistamine, to destroy excess histamine and that this chemical to normal physiological levels.
In addition to its antihistamine, vitamin C has many other actions in the body. Like histamine, Vitamin C is also a neuromodulator, and as an immunomodulator. In fact, on the basis of the above information in this thesis is not an exaggeration to that vitamin C is the counterpart of histamine and molecular surveillance. Unfortunately for humans, vitamin C can not be synthesized in the body, so it must be filled in foods or nutritional supplements. If humans could synthesize vitamin C, a person would be about £ 150 12 grams of vitamin C per day. It is 133-200 times more U.S. (RDA) for vitamin C. This statistic does highlight the fact that there is a huge difference between the RDA of vitamin C to prevent rare diseases, and maintain optimum physical and mental health.
suboptimal amounts of vitamin C in the blood and tissue histamine can allow dangerous levels. Histamine is competing with other neurotransmitters and excess histamine can control and inhibition of other neurotransmitters. This can lead to anxiety and depression. Histamine release both norepinephrine and dopamine, and these two neurotransmitters Beyond may precipitate mania and psychosis, respectively. Histamine can also be involved in AD (Passani, Bacciottini, Mannaioni, and Blandine, 2000). Stress releases histamine, which in turn releases a number of hormones Stress can cause serious injury if stress is chronic. The histamine and other neurotransmitters dominates, may also deregulate HPA axis by stimulating the pituitary and adrenal glands.
The molecule cyclic AMP (cAMP) is an important regulator metabolism. Intense allow the maintenance of physical and mental health. Low levels can cause asthma, depression, and perhaps even cancer. Histamine decreases the levels of cAMP by a mechanism that is not fully clarified, because it may have to do with the antagonist calcium through cAMP. Vitamin C increases the levels of cAMP for at least three methods: direct histamine degrading cAMP synergy with producers, and inhibiting the enzyme (phosphodiesterase) that degrades cAMP. This way, you can reduce, prevent or reverse asthma, depression and cancer. Vitamin C also helps to reverse asthma by preventing the synthesis of inflammatory mediators of arachidonic acid (AA) and PGF2a. CAMP also inhibits the release of histamine (Mohsenin and Dubois, 1987).
It has been demonstrated in this thesis that Vitamin C is very beneficial for mental health in different ways. Benefits of Vitamin C Mental Health, both antihistamines and their effects in many other ways too. It is very unfortunate that humans can not synthesize their own vitamin C. The animals that synthesize their own cancer of vitamin C much less than humans. However, the recommended daily dose of vitamin C is a miserable 60-90 mg / day, just enough to prevent certain diseases which are rare in developed countries. The time will come when vitamin C is recommended by doctors and nutritionists at doses that are appropriate weight Single Occupancy — about eight grams per 100 pounds, twice as suggested by Nobel laureate Linus Pauling.
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About the Author
Dr. Jensen is both a consultant and author in the BioMedical and Nutrition fields. He has previously written a book on both topics, The Failures of American Medicine, published in 2002. Dr. Jensen has also written a doctoral dissertation on how Vitamin C can reduce stress and allergies via its antihistamine effect. He has worked in a broad range of BioMedical fields, such as gene regulation, cancer research, and HIV vaccine development. However, Dr. Jensen eventually decided that helping people more directly would be more rewarding for everyone involved. He has since helped clients with dozens of different ailments. Dr. Jensen is a practitioner in the field of Metabolic Typing, which characterizes different biochemistries among people based on certain physical and behavioral traits they have.
You can contact Dr. Jensen at 1-800-390-5365, or mail him at drjensen@individualizednutrition.com.
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